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Medication Dosing

Weight-based and AUC-based dosing calculators for critical medications.

Clinical Overview

Accurate medication dosing is critical for patient safety, especially for narrow therapeutic index drugs and weight-based pediatric or critical care protocols. These calculators help standardize complex dosing calculations.

Common Use Cases

  • Weight-based pediatric dosing
  • AUC-based vancomycin dosing
  • Inotrope and vasopressor dosing (mcg/kg/min)
  • Renal dose adjustments based on CrCl

Clinical Pearls

Ideal vs Actual Body Weight

For obese patients, many hydrophilic drugs (like aminoglycosides) should be dosed based on Adjusted Body Weight (ABW) rather than Total Body Weight (TBW) to prevent toxicity.

Vancomycin AUC/MIC

Guidelines now recommend AUC/MIC ratio of 400-600 (assuming MIC of 1) for serious MRSA infections, replacing previous trough-only monitoring strategies.