Enter Patient Values
Provide laboratory values to assess alcoholic hepatitis severity
* Required fields
Normal range: 0.3-1.2 mg/dL
Normal range: 11-13.5 seconds
Default: 12.0 seconds
Maddrey's Discriminant Function Formula
Formula:
DF = 4.6 × (PT - Control PT) + Total Bilirubin
• PT = Patient's prothrombin time (seconds)
• Control PT = Laboratory control PT (typically 12 seconds)
• Total Bilirubin = Serum total bilirubin (mg/dL)
• DF ≥32 indicates severe alcoholic hepatitis
About Maddrey's Discriminant Function
Maddrey's Discriminant Function (DF) is a prognostic scoring system used to assess the severity of alcoholic hepatitis and guide treatment decisions, particularly regarding corticosteroid therapy.
The formula incorporates the patient's prothrombin time (PT) and total bilirubin level, with a discriminant function value of 32 or higher indicating severe alcoholic hepatitis and high 28-day mortality risk.
Patients with DF ≥32 have approximately 35% 28-day mortality and may benefit from corticosteroid therapy. The score helps identify patients who require intensive monitoring and specific therapeutic interventions.
Note: Maddrey's DF is specifically designed for alcoholic hepatitis and should be used in conjunction with clinical judgment. Always consult with a hepatologist for comprehensive evaluation and treatment planning.